Formulasi Granul Effervescent Ekstrak Aseton Rimpang Kencur (Kaempferia Galanga L.) dengan Variasi Konsentrasi Polivinilpirolidon
-
Nurul Afifi Lobubun
*
Universitas Islam Indonesia, Yogyakarta,
Indonesia
- Lutfi Chabib Universitas Islam Indonesia, Yogyakarta, Indonesia (*) Corresponding Author
Abstract
Kencur is one of the plants that is useful as an anthelmintic drug. This study aims to formulate effervescent granules of acetone extract of Kencur rhizome (Kaempferia galanga L.) with various concentrations of polyvinylpyrrolidone. Kencur rhizome extraction was carried out by maceration method using acetone solvent for 3 days then filtered and concentrated with a rotary vacuum evaporator. The extract was granulated using the wet granulation method with a ratio of citric acid monohydrate and tartaric acid 1:2. Variations in PVP concentrations were 2%, 4%, and 6%. Physical evaluation of granules includes Density and Porosity, Compressibility Index (Carr Index), Flow Time, and Angle of Bed. The best porosity was in formula 3 with 30.47±1.471. The compressibility index (Carr Index) of the three formulas is in the range of 515%. The best dosage flow times were formulas 2 and 3 with 8.67±0.526 and 7.58±0.344. The Hausner Ratio of the three formulas is below 1.25. The angles of repose in formulas 1 and 2 are 24.94º and 29.74º with a recline angle <40. The foam stopping time is 23 seconds. From theresults abtained it can be concluded that the formula with good pharmaceutical properties is formula 3 with a variation of 6% pvp concentration.
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References
Anderson, N.R., Banker, and G.S, Fonner, E., 1981, “Granulation and Tablet Characteristic in Pharmaceutical Dosage Forms Tablets”. Liebermen, H.A, Volume III. Marcel Dekker Inc, New York.
Ansel,H,C.,1989. “PengantarBentukSediaanFarmasi”, Edisi Keempat, penerjemah Farida Ibrahim, Penerbit Universitas Indonesia, Jakarta
Ariswati, W., Siswanto, A., Hartanti., D 2010. Pengaruh Gelatin, Amilum dan PVP Sebagai Bahan Pengikat Terhadap Sifat Fisik Tablet Ekstrak Temulawak. Journal Pharmacy. 7(2): 58-59.
Banker, S.G and Anderson, R.N., 1986, Tablet In Lachman, L. Lieberman, The Theory and Practice of Industrial Pharmacy, 3 rd ed., Lea and Febiger, Philadelphia. 643-704
Dash P.R, Mou K.W, Erina I.N, Ripa F.A, Al Masud K.N, Ali M.S. Study of Anthelmintic and Insecticida Activities of Different Extracts of Kaempferia galangal. International Journal of Pharmaceutical Science and Research Vol. 8(2): 729-733.
Departemen Kesehatan Republik Indonesia. 2006. Hairani B, dkk. Prevalensi soil transmitted helminth 48 Jurnal Buski Vol. 5, No. 1, Juni 2014, halaman 43-48 Pedoman Pengendalian Cacingan. Jakarta : Direktorat Jenderal PP&PL.
Depkes RI 1986. Sedian Galenik. Jakarta: DitjenPOM. Hal. 12, 26.
Ditjen POM, 1979. Farmakope Indonesia Edisi III. Departemen Kesehatan RI;Jakarta.
Ditjen POM 1995.Farmakope Indonesia, Edisi Keempat, Departemen Kesehatan Republik Indonesia : Jakarta.
Fonner, D. E., Anderson, N. R., and Banker, G. S., 1981, Granulation Tablet Characteristic in Pharmaceutical Dosage Form. Tablet, Vol II, Lieberman, H. A., and Lachman L., (Editor), Marcel Dekker Inc., New york. 299.
Jones, David. 2008. Fast Track : Pharmaceutics Dosage Form and Design, London : London Pharmaceutical Press
Lachman, L., Lieberman, H.A., Kanig, J.L. 1994. Teori dan Praktek Farmasi Industri. Edisi III. Jakarta: UI Press. Halaman 654
Lachman, L., Lieberman, H., A., and Kanig, J., L., 2005., Terjemahan Teori dan Praktek Farmasi Industri., Oleh Siti Suyati. 1994., UIPress., Jakarta.
Lestari, Budi Susiana, Lisa Natalia. 2007. Optimasi Natrium Sitrat dan Asam Fumarat Sebagai Sumber Asam Dalam Pembuatan Effervescent Ekstrak Temulawak (Curcuma xanthorrhiza Roxb) Secara Granulasi Basah. Majalah Farmasi Indonesia.18(1): 21-28
Liebermen, H.A., Rieger, M.M. & Banker, G.S.1996. Pharmaceutical Dosage Forms Disperse System Volume II Second Edition. Marcel Dekker Inc : New York
Mohrle, R. 1980. Effervescenf Tablet in Pharmaceutical Dosage Form Tablet, Volume I, 3rd edition. Marcel Dekker Inc, New York: 225-255
Mohrle, R. 1989. Effervescent Tablet in Pharmaceutical Dosage Form Table.Marcel Dekker Inc. New York Niazi, Sarfaraz K., 2009. Handbook of Pharmaceutical Manufacturing Formulation Vol.1, 2nd ed. London : Informa Healthcare
Parrot, E.L., 1971, Pharmaceutical Technology Fundamental Pharmaceutitics, The Third Revision, Burgess Publishing Company, Minneapolis
Rahbani-Nobar ME, Rahimi-Pour A, Rahbani-Nobar M, Adi-Beig F, Mirhashemi SM. Total antioxidant capacity, superoxidedismutase and glutathione peroxidase in diabetic patients. MedicalJournal of Islamic Academy of Sciences 1999;12(4):109-14.
Rowe, R.C., Sheskey, P.J.& Owen, S.C.2006. Handbook of Pharmaceutical Excipients. 6th edition. Pharmaceutical Press, American Pharmaceutical Association
Sekar, T.R. 2011. Manfaat Umbi dan Rimpang Bagi Tubuh Kita, Siklus, Yogyakarta
Umar MI, Asmawi MZ, Sadikun A, Atangwh IJ, Yam MF, Altaf R and Ahmed A: Bioactivity-Guided Isolation of Ethyl-pmethoxycinnamate, an Anti-inflammatory Constituent, from Kaempferia galanga L. Extracts. Molecules 2012; 17: 8720-8734.
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