Formulasi dan Uji Sifat Fisik Sediaan Krim dari Ekstrak Watermelon Rind ((Citrullus lanatus).(Thunb)).
Abstract
Indonesia has a tropical climate which makes the body produce excess oil. This triggers the occurrence of acne, because it can clog skin pores and cause the formation of bacterial colonies. Watermelon is a fruit that has many health benefits. Generally, people consume the contents and throw away the white flesh and skin (watermelon rind), even though this part has good benefits for the skin because it contains several biochemical compounds that act as antibacterial. One of the preparations used for skin problems is cream. This study aims to produce a formula for the preparation of watermelon rind extract cream that complies with pharmaceutical requirements and is stable in storage. Watermelon rind cream preparation is made with a concentration of watermelon rind extract, namely FI 7.5%; FII 12.5%, and FIII 20%. Finished preparations were tested for physical stability which included organoleptic tests, homogeneity, pH, irritation tests, cream type tests, spreadability and stability tests. The watermelon rind extract cream obtained is green in color, has a distinctive smell of extract and rose oil, is homogeneous, and is of the M/A type. The pH of the watermelon rind extract cream is in a range that is still acceptable to the skin and has good spreadability and does not cause irritation to the skin. During the storage period, the watermelon rind extract cream did not experience physical changes and homogeneity, and did not experience a significant decrease in pH and spreadability with a p-value > 0.05. This shows that the preparation of watermelon rind extract cream meets pharmaceutical requirements and is stable during storage.
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References
anggraeni, Y., Ambarwati, T., Miranti, I., & Fakultas, E. G. (2019). Citrula Gel Dari Limbah Kulit Buah Semangka (Citrullus Lanatus (Thunb.) Matsum & Nakai) Sebagai Antijerawat (Acne Vulgaris. Pharmacy: Jurnal Farmasi Indonesia (Pharmaceutical Journal Of Indonesia), 16(01), 1–9.
Ardhany, S. D., Puspitasari, Y., Meydawati, Y., & Novaryatiin, S. (2019). Formulasi Sediaan Krim Anti Acne dan Uji Aktivitas Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) terhadap Propionibacterium acnes. Jurnal Sains Dan Kesehatan, 2(2), 121–126.
Blaskovich, M. A. T., Elliott, A. G., Kavanagh, A. M., Ramu, S., & Cooper, M. A. (2019). In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria. In Scientific Reports (Vol. 9, Issue 1).
Borman, I. O., & Sulastri, E. (2015). Gel Anti Jerawat Ekstrak Daun Buta-Buta ( Excoecaria Agallocha L .) Dan Pengujian Antibakteri Staphylococcus Epidermidis. Galenika Journal Of Pharmacy, 1(2), 65–72.
Dewi, N. P. Y. A., Pebriani, N. L. G. W., Duarsa, P. A., Warnaya, P. C. I., Candraningrat, I. D. A. A. D., & Arisanti, C. I. S. (2020). Formulasi Dan Uji Pelepasan Krim Ekstrak Etanol Daun Jambu Biji Dengan Potensi Antijerawat. Jurnal Kimia, 14(2), 119.
Genatrika, E., Isna Nurkhikmah, I., & Hapsari, In. (2016). Formulasi Sediaan Krim Minyak Jintan Hitam (Nigella Sativa L.) Sebagai Antijerawat Terhadap Bakteri Propionibacterium Acnes. Pharmacy: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 13(2), 192–201.
Gunawan, A. (2020). Optimasi Formula Sampo Ekstrak Lapisan Putih Kulit Buah Semangka (Citrullus Vulgaris Schrad) Dengan Kombinasi Hpmc Dan Sarkosyl Serta Uji Aktivitasnya Pada Jamur Pityrosporum Ovale. Jurnal Kesehatan Tujuh Belas (Jurkes TB), 1(2), 105–123.
Handayani, F. F., Pangesti, L. A. T., & Siswanto, E. (2019). Uji Aktivitas Ekstrak Etanol Gambir (Uncaria Gambir Roxb.) Terhadap Penyembuhan Luka Bakar Pada Kulit Punggung Mencit Putih Jantan (Mus Musculus). Jurnal Ilmiah Manuntung, 1(December 2015), 133–139.
Hosea Jaya Edy, Marchaban, Wahyuono, S., & Nugroho, A. E. (2016). Formulasi Dan Uji Sterilitas Hidrogel Herbal Ekstrak Etanol Daun Tagetes Erecta L. Pharmacon, 5(2), 9–16.
Irhamna, A. (2019). Formulasi Sediaan Sabun Padat dari Ekstrak etanol Kulit Putih Buah Semangka (Citrullus lanatus (Thunb.) Matsumura & Nakai) Kombinasi Madu (Mel depuratum).
Kemenkes RI. (2020). Farmakope Indonesia edisi VI. In Departemen Kesehatan Republik Indonesia.
Kusmiati, K., Priadi, D., & Rahayu, R. K. B. R. (2017). Antibacterial Activity Test, Evaluation of Pharmacognosy and Phytochemical Screening of Some Extracts of Globe Amaranth (Gomphrena globosa). The Journal of Pure and Applied Chemistry Research, 6(1), 27–33.
Martin Eric.L. (1971). Dispensing of Madication (7th Editio). Mack Publishing Company.
Moore, T. A. (2009). Recurrent Epidural Abscess Caused by Propionibacterium Acnes. 92–95.
Nuralifah, N., Armadany, F. I., Parawansah, P., & Pratiwi, A. (2019). Uji Aktivitas Antibakteri Sediaan Krim Anti Jerawat Ekstrak Etanol Terpurifikasi Daun Sirih (Piper betle L.) dengan Basis Vanishing Cream Terhadap Propionibacterium acne. Pharmauho: Jurnal Farmasi, Sains, Dan Kesehatan, 4(2).
Odewunmi, N A, Umoren, S. A., & Gasem, Z. M. (2014). Journal of Industrial and Engineering Chemistry Utilization of watermelon rind extract as a green corrosion inhibitor for mild steel in acidic media. Journal of Industrial and Engineering Chemistry, 1–9.
Odewunmi, Nurudeen A, Umoren, S. A., Gasem, Z. M., Ganiyu, S. A., & Muhammad, Q. (2015). L -Citrulline : An Active Corrosion Inhibitor Component Of Watermelon Rind Extract For Mild Steel In Hcl Medium. Journal Of The Taiwan Institute Of Chemical Engineers, 000, 1–9.
Oseni, O. A., & Okoye, V. I. (2013). Studies of Phytochemical and Antioxidant Properties of The Fruit of Watermelon (Citrullus lanatus). (Thunb). 27(27), 508–514.
Rahman, B. (2010). Phytochemical Investigation Of Citrullus Lanatus ( Watermelon ) Rind Declaration By Research Candidate.
Rimando, A. M., & Perkins-Veazie, P. M. (2005). Determination Of Citrulline In Watermelon Rind. 1078, 196–200.
Salwa, S., Abd Kadir, M. Bin, & Sulistyowati, Y. (2020). Formulasi Dan Evaluasi Sediaan Spray Gel Tabir Surya Fraksi Etil Asetat Daun Cempedak (Artocarpus Integer (Thunb.) Merr.) Dengan Kombinasi Basis Hpmc Dan Karbopol 940. Jurnal Mahasiswa Kesehatan, 2(1), 12.
Shafira, R., Agung, S. E., & Okzelia, S. D. (2022). Formulasi Dan Evaluasi Gel Dari Ekstrak Kulit Putih Semangka (Citrullus Lanatus [Thunb.] Matsum. & Nakai) Sebagai Pelembap Kulit. Jurnal Sabdariffarma, 9(2), 33–44.
Sumbayak, A. R., & Diana, V. E. (2019). Formulasi Hand Body Lotion Ekstrak Etanol Kulit Buah Semangka (Citrillus vulgaris) untuk Pelembab Kulit. Jurnal Dunia Farmasi, 2(2), 70–76.
Supomo, S., Sukawati, Y., & Basyar, F. (2017). Formulasi Gelhand Sanitizer Dari Kitosan Dengan Basis Natrium Karboksimetilselulosa. Jurnal Ilmiah Manuntung, 1(1), 31.
Swastika, A., Mufrod, & Purwanto. (2013). Antioxidant Activity Of Cream Dosage Form Of Tomato Extract (Solanum lycopersicum L.). Traditional Medicine Journal, 18(3), 2013.
Syakri, S., & Arsul, M. I. (2019). Jurnal Farmasi FKIK UINAM Vol.2 2019. 2.
Tranggono, R. ., & Latifah, F. (2007). Buku Pegangan Ilmu Pengetahuan Kosmetik. Gramedia Pustaka Utama.
Widyaningtias, Yustiantara, & Paramita. (2014). Uji Aktivitas Antibakteri Ekstrak Terpurifikasi Daun Sirih Hijau (Piper betle L.) Terhadap Bakteri Propionibacterium acnes. Jurnal Farmasi Udayana, 50–53.
Wintariani, N. P., Mahartha, I. K. P., & Suwantara, I. P. T. (2021). Sifat Fisika Kimia Sediaan Vanishing Krim Anti Jerawat Ekstrak Etanol 96% Daun Belimbing Wuluh (Averrhoa bilimbi L.). Widya Kesehatan, 3(1), 26–34.
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