Aktivitas Antibakteri Sediaan Gel dari Fraksi Aktif Daun Sintrong (Crassocephalum Crepidioides (Benth) S Moore)


  • Muharni Saputri * Mail Universitas Tjut Nyak Dhien, Medan, Indonesia
  • Vriezka Mierza Universitas Tjut Nyak Dhien, Medan, Indonesia
  • (*) Corresponding Author
Keywords: Sintrong, Parmeraan, Gel, Staphylococcus aureus, Escherichia coli

Abstract

Indonesia is a tropical country that allows bacteria to easily grow and develop, especially in the skin. The drugs used are very diverse, generally from corticosteroids, which have side effects. This encourages the need for research on antimicrobial drugs from natural ingredients such as herbs that have high potency and relatively low side effects. Sintrong plants (Crassocephalum crepidioides (Benth.) S. Moore) are found in Parmeraan Village, Dolok District, North Padang Lawas Regency, North Sumatra Province. This plant is thought to contain alkaloid compounds and tannins as antimicrobials. This research method is an experimental study with the maceration method of ethanol extract and fractionation of n-hexane, ethyl acetate, phytochemical screening, making topical gels 20%, 10%, and 5% with parameters of pH, homogeneity, viscosity, dispersibility and adhesion as well as Antibacterial test against pure cultured bacteria using agar diffusion method using metal buffer, the bacteria used were gram-positive bacteria (Staphylococcus aureus ATCC 29737) and gram-negative bacteria (Escherichia coli ATCC 10536). The results showed that the ethanol extract of Sintrong leaves can be formulated in the form of a gel. The results of the evaluation that have been carried out on the methanol extract gel of Sintrong leaves show that the preparation has met the gel requirements. The formula that has the best antibacterial activity is Formula 1 which provides an inhibitory diameter of 17.10 mm and 18.75 mm for Escherichia coli and Staphylococcus aureus bacteria.

Downloads

Download data is not yet available.

References

Hidayat, R.S., dan Napitupulu, R.M. (2015). Kitab Tumbuhan Obat. Jakarta: Agriflo.

Sari, W. (2016). Uji Aktivitas Antibakteri Ekstrak Etanol dan Fraksi Daun Sintrong (Crassocephalum crepidioides (Benth.) S.Moore) terhadap Bakteri Eschericia coli dan Staphylococcus aureus. Medan: Sumatera Utara: Fakultas Farmasi: Universitas Sumatera Utara.

Utami, M. (2018). Analisis Kadar Fenolik, Flavonoid, dan Aktivitas Antioksidan Ekstrak Etanol Serbuk Harendong (Melastoma affine D.Don), Sintrong (Crassocephalum crepidioides (Benth.) S.Moore) dan Jonge (Emilia sanchifolia). Bandung: Fakultas Teknik Pangan: Universitas Pasundan.

Manurung, M. (2018). Formulasi Sediaan Gel Hand Sanitizer dari Ekstrak Etanol Daun Sintrong (Crassocephalum crepidioides (Benth.) S.Moore). Medan, Sumatera Utara: Fakultas Farmasi: Institut Kesehatan Helvetia.

Roni, A., dan Budiana, W. (2018). Pemanfaatan Tumbuhan Tespong (Oenanthe javanica DC), Sintrong (Crassocephalum crepidioides (Benth.) S.Moore, Pohpohan (Pilea trinervia W) dalam Menghambat Pertumbuhan terhadap Bakteri Staphylococcus epidermidis dan Pseudomonas aerugenosae.. Jurnal of Pharmacopolium, 122-130.

Simanungkalit, E.R., Duniaji, A.S., dan Ekawati, I.G.A. (2020). Kandungan Flavonoid dan Aktivitas Antibakteri Ekstrak Etanol Daun Sintrong (Crassocephalum crepidioides (Benth.) S.Moore) terhadap Bakteri Bacillus cereus. Jurnal Itepa, 9(2): 202-210.

Yumniati, I., Yuniarni, U., Hazar, S. (2016). Uji Aktivitas Ekstrak Etanol Daun Sintrong (Crassocephalum crepidioides (Benth.) S.Moore) terhadap Mencit Galur DDY. Prosiding Farmasi, (pp. 413-419).

Apristiani, D., dan Puji, A. (2005). Isolasi Komponen Aktif Antibakteri Ekstrak Kloroform Daun Mimba (Azdirachta indica A.Juss.) dengan Bioautografi. Jurnal Biofarmasi , 43-46.

Hidayat, R.S dan Napitupulu, R.M. (2015). Kitab Tumbuhan Obat. Jakarta: Agriflo.

Krisyanella, Dachriyanus dan Marlina. (2011). Karakterisasi Simplisia dan Ekstrak serta Isolasi Senyawa Aktif Antibakteri dari Daun Karamunting (Rhodomyrtus tomentosa (W.Ait) Hassk). Pasca Unand , 1-17.

Tranggono, R. I. S., dan Latifah, F. (2014). Kosmetologi edisi 2. Penerbit Sagung Seto. Jakarta.

Voigt, R. (1994). Buku Pelajaran Teknologi Farmasi Edisi Ke-5. Diterjemahkan oleh Soendani Noerono. Gadjah Mada Press. Yogyakarta.


Bila bermanfaat silahkan share artikel ini

Berikan Komentar Anda terhadap artikel Aktivitas Antibakteri Sediaan Gel dari Fraksi Aktif Daun Sintrong (Crassocephalum Crepidioides (Benth) S Moore)

Dimensions Badge
Article History
Submitted: 2020-10-05
Published: 2020-10-30
Abstract View: 877 times
PDF Download: 1311 times
Section
Articles