Formulasi dan Evaluasi Gel Pelembap Ekstrak Mesokarp Semangka [Citrullus lanatus (Thunb.) Matsum. & Nakai] sebagai Antioksidan
-
Sari Defi Okzelia
*
Sekolah Tinggi Ilmu Kesehatan Bani Saleh, Bekasi,
Indonesia
- Waffiyyatul Mardiyyah Sekolah Tinggi Ilmu Kesehatan Bani Saleh, Bekasi, Indonesia (*) Corresponding Author
Abstract
Dry skin is the most common skin problem, so moisturizers are used to prevent it. White skin (mesocarp) of watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai] (MW) has the potential to be formulated into a moisturizing gel preparation since it contains vitamins and citrulline which also possess antioxidant activity. This study aimed to formulate a moisturizing gel preparation from MW extract as an antioxidant. MW was extracted by maceration using 70% ethanol and formulated into moisturizing gel preparation at concentrations of 5% (F1), 10% (F2), and 15% (F3). Gel preparations were evaluated physically, and determined their moisture content and antioxidant activity. MW extract was a brown color with 25.02% yield. The evaluation results showed that all formulations met the standard parameters of good gel preparations including organoleptic, homogeneity, spread-ability, adhesion, pH, and viscosity, and did not irritate the skin. The skin moisture after application of F1, F2, and F3 respectively were 29.49%; 36.63%; and 43.48%. IC50 values for F1, F2, and F3 respectively were 156.42; 149.24, and 138.05 µg/mL. The moisturizing gel preparation from MW extract met all the standard parameters of good gel preparation, could increase the percentage of skin moisture, and had moderate antioxidant activity.
Downloads
References
Agoes, G. (2009). Teknologi Bahan Alam (Serial Farmasi Industri-2) ed Revisi. ITB.
Amin, A., Riski, R., & Sutamanggala, N. R. (2021). Antioxidant Activity of Mesocarp Extract of Watermelon ( Citrullus lanatus ( Thunb ) Matsun & Nakai ) Using ABTS Method. Journal of Pharmaceutical and Medicinal Sciences, 6(1), 1–5. https://doi.org/https://doi.org/10.32814/jpms.v6i1
Anggraeni, Y., Ambarwati, T., Miranti, I., & Genatrika, E. (2019). Citrula Gel dari Limbah Kulit Buah Semangka (Citrullus lanatus (Thunb.) Matsum & Nakai) sebagai Antijerawat (Acne vulgaris). Pharmaceutical Journal of Indonesia, 3(01), 1–9. https://doi.org/https://doi.org/10.30595/pharmacy.v16i1.2964
Aventi. (2015). Penelitian pengukuran kadar air buah. Journal Seminar Nasional Cendikiawan, 12–27. https://doi.org/https://doi.org/dx.doi.org/10.25105/semnas.v0i0.108
Ekayanti, N. L. P. S., Darsono, F. L., & Wijaya, S. (2019). Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Semangka (Citrullus lanatus). Jurnal Farmasi Sains Dan Terapan, 6(1), 38–45. https://doi.org/10.33508/jfst.v6i1.2011
Elmitra. (2017). Dasar-dasar Farmasetika dan Sediaan Semi Solid (1st Editio). Deepublish. Yogyakarta.
Eugresya, G., Avanti, C., & Uly, S. A. (2017). Pengembangan Formula dan Uji Stabilitas Fisik-pH Sediaan Gel Facial Wash yang Mengandung Ekstrak Etanol Kulit Kayu Kesambi. Media Pharmaceutica Indonesiana, 1(4), 181–188. https://doi.org/10.24123/mpi.v1i4.769
Febriani, A., Maruya, I., & Sulistyaningsih, F. (2020). Formulasi dan Uji Iritasi Sediaan Gel Kombinasi Ekstrak Etanol Rimpang Kencur (Kaempferia galanga L.) dan Ekstrak Etanol Herba Pegagan (Centella asiatica (L.) Urban). J Sainstech Farma, 13(1), 45–54. https://doi.org/https://doi.org/10.37277/sfj.v13i1
Hasanah, M., Apriyanti, D., & Patmayuni, D. (2020). Perbandingan Antioksidan Ekstrak Etanol Daun Gaharu (Aqularia malaccensis L.) dan Ketiga Fraksi Berbagai Pelarut (Heksan, Etil Asetat, dan Air). Jurnal Penelitian Sains, 22(1), 25–33. https://doi.org/10.56064/jps.v22i1.552
Irianto, I. D. K., Purwanto, P., & Mardan, M. T. (2020). Aktivitas Antibakteri dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau (Piper betle L.) Sebagai Alternatif Pengobatan Mastitis Sapi. Majalah Farmaseutik, 16(2), 202-20=10. https://doi.org/10.22146/farmaseutik.v16i2.53793
Julianto, T. S. (2019). Fitokimia Tinjauan Metabolit Sekunder dan Skrining Fitokimia. Universitas Islam Indonesia. Yogyakarta.
Kosasih, K., Sumaryono, W., Mudhakir, D., Supriyono, A., Christian, Y. E., & Debora, R. (2021). Effects of Gelatin and Glutaraldehyde Concentrations on Characteristics of Cantigi (Vaccinium Varingiaefolium Miq.) Extract Loaded Gelatin Nanoparticles as Antioxidant. Journal of Halal Product and Research, 4(1), 1. https://doi.org/10.20473/jhpr.vol.4-issue.1.1-7
Kurniasih, N., Kusmiyati, M., Nurhasanah, Puspita Sari, R., & Wafdan, R. (2015). Potensi Daun Sirsak (Annona Muricata Linn), Daun Binahong (Anredera Cordifolia (Ten) Steenis), Dan Daun Benalu Mangga (Dendrophthoe Pentandra) Sebagai Antioksidan Pencegah Kanker. Jurnal Istek, 9(1), 162–184. https://journal.uinsgd.ac.id/index.php/istek/article/view/182
Laras, A. A. I. ., Swastini, D. ., Wardana, M., & Wijayanti, N. P. A. . (2014). Uji Iritasi Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.). Jurnal Farmasi Udayana, 3(1), 74–77. https://doi.org/https://ojs.unud.ac.id/index.php/jfu/article/view/10809
Manggau, M. A., Damayanty, R., & M, L. (2017). Uji Efektivitas Kelembaban Sabun Transparan Ekstrak Rumput Laut Cokelat ( Sargassum Cristaefolium C . Agardh ) dengan Variasi Konsentrasi Sukrosa. Journal of Pharmaceutical and Medicinal Sciences, 2(1), 21–26. https://doi.org/https://doi.org/10.30799/jpmr
Mardiana, Li., Sunarni, T., & Murukmihadi, M. (2019). Optimasi Kombinasi Carbomer dan CMC Na Dalam Sediaan Gel. Pharmacy Medcal Journal, 2(2), 80–85. https://doi.org/https://doi.org/10.30595/pharmacy.v17i1.6261
Muthmainnah, B. (2017). Skrining Fitokimia Senyawa Metabolit Sekunder Dari Ekstrak Etanol Buah Delima (Punica granatum L.) Dengan Metode Uji Warna. Media Farmasi, 13(2). https://doi.org/https://doi.org/10.32382/mf.v13i2
Okzelia, S.D., Hendrati, D., & Iljas, N. (2017). Isolasi dan Pemisahan Senyawa Alkaloid dari Buah Mahkota Dewa (Phaleria macrocarpa Boerl.) dengan Metode Kromatografi Cair. Journal of Nursing and Health, 1(2), 1–7. https://doi.org/https://doi.org/10.25099/stkbs.0102091 75
Okzelia, S. D., & Nurdaini, M. (2019). Antioxidant Activity of Pidada (Sonneratia caseolaris (L.) Engl.) Fruit Extract by DPPH Method. Singapore International Multidisciplinary Academic Conference (SIMAC), 1–8. https://www.researchgate.net/publication/338764485
Rawlings, A. V. (2014). Molecular basis for stratum corneum maturation and moisturization. British Journal of Dermatology, 171, 19–28. https://doi.org/https://doi.org/10.1111/bjd.13303
Rizkiah, S., Okzelia, S. D., & Efendi, A. S. (2021). Formulasi dan Evaluasi Gel dari Ekstrak Kulit Putih Semangka (Citrullus lanatus [Thunb.] Matsum. & Nakai). Jurnal Sabdariffarma, 3(2), 1–11. https://doi.org/https://doi.org/1053675/jsfar.v3i2.394
Rohmani, S., Ningrum, S. K., Wardhani, W. D., & Kundarto, W. (2022). Pengaruh Variasi Konsentrasi Surfaktan Iselux Ultra Mild pada Formulasi Hydrating Facial Wash Potassium Azeloyl Diglycinate. Jurnal Kefarmasian Indonesia, 12(1), 58–68. https://doi.org/10.22435/jki.v0i0.4969
Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2017). Handbook of Pharmaceutical Excipients (8th ed). Pharmaceutical Press.
Sandhiutami, N. M. D., Rahayu, L., Oktaviani, T., & Sari, L. Y. (2014). Uji Aktivitas Antioksidan Rebusan Daun Sambang Getih (Hemigraphis bicolor Boerl.) dan Sambang Solok (Aerva sanguinolenta (L.) Blume) Secara In Vitro. Paper Knowledge . Toward a Media History of Documents, 5(2), 1–5. https://doi.org/https://adoc.pub/uji-aktivitas-antioksidan-rebusan-daun-sambang-getih-hemigra.html
Slamet, S., Anggun, B. D., & Pambudi, D. B. (2020). Uji Stabilitas Fisik Formula Sediaan Gel Ekstrak Daun Kelor (Moringa Oleifera Lamk.). Jurnal Ilmiah Kesehatan, 13(2), 115–122. https://doi.org/10.48144/jiks.v13i2.260
Sowmya J, D. (2015). Topical Gels: A Recent Approach for Novel Drug Delivery. International Journal of Health Sciences and Research (IJHSR), 5(10), 302–312.
Sulistyarini, I., Sari, D. A., & Wicaksono, T. A. (2019). Skrining Fitokimia Senyawa Metabolit Sekunder Batang Buah Naga (Hylocereus polyrhizus). Jurnal Ilmiah Cendekia Eksakta, 56–62. https://doi.org/https://doi.org/10.3194/CE.V5I1.3322
Suryani, N., Mubarika, D. N., & Komala, I. (2019). Pengembangan dan Evaluasi Stabilitas Formulasi Gel yang Mengandung Etil p-metoksisinamat. Pharmaceutical and Biomedical Sciences Journal (PBSJ, 1(1), 29–36. https://doi.org/https://doi.org/10.15408/pbsj.v1i1.12688
Utami, P. (2008). Buku Pintar Tanaman Obat (Edisi 1). PT Agromedia Pustaka. Jakarta.
Voight, R. (1994). Buku Pelajaran Teknologi Farmasi (5th ed.). Gadjah Mada University Press. Yogyakarta.
Yuniarsih, N., Akbar, F., Lenterani, I., & Farhamzah. (2020). Formulasi Dan Evaluasi Sifat Fisik Facial Wash Gel Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) Dengan Gelling Agent Carbopol. Pharma Xplore, 5(2), 57–67. https://doi.org/https://doi.org/10.36805/jpx.v5i2
Bila bermanfaat silahkan share artikel ini
Berikan Komentar Anda terhadap artikel Formulasi dan Evaluasi Gel Pelembap Ekstrak Mesokarp Semangka [Citrullus lanatus (Thunb.) Matsum. & Nakai] sebagai Antioksidan
Pages: 30-39
Copyright (c) 2023 Sari Defi Okzelia, Waffiyyatul Mardiyyah
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (Refer to The Effect of Open Access).
